Mesacol 1gm Suppository (Mesalazine)

Introduction

Treating inflammatory bowel diseases like Crohn’s disease and ulcerative colitis needs targeted and effective treatment options. Mesacol 1gm Suppository is one of such medications widely used in Australia. This medication delivers the active pharmaceutical ingredient (API) mesalazine straight to the affected areas of our lower bowel, giving relief from inflammation and related symptoms. Patients struggling with proctitis and other forms of ulcerative colitis sometimes recovered from this localized therapy, which offered a reduction of flare-ups and maintained remission.

What is Mesacol 1gm Suppository?

Mesacol 1gm Suppository is a medication containing 1 gram of the active pharmaceutical ingredient (API) mesalazine (also called 5-aminosalicylic acid). It is particularly designed for rectal administration to manage inflammation in the lower part of the colon and rectum. The suppository formulation enables the medicine to act targeted, exactly where inflammation occurs, making it a highly effective drug for conditions such as proctitis and ulcerative colitis. This targeted or local drug delivery helps to reduce systemic absorption, minimizing the risk of side effects generally associated with oral formulation.

It is manufactured by Sun Pharmaceutical Industries Ltd, a globally popular pharma company. Mesalazine Suppository 1gm results from the company’s wide experience and dedication to quality. Sun Pharma, founded in 1983, has developed to become one of the largest pharma companies worldwide for generic pharmaceutical production.

Uses of Mesacol 1gm Suppository

The typical Mesacol Suppository Uses include:

• Management of ulcerative colitis, particularly mild to moderate situations involving the sigmoid colon and rectum.
• Treatment of proctitis (an inflammation of the rectal lining) causing bleeding, pain, and urgency.
• Maintenance remedy to avoid relapse in individuals with ulcerative colitis.
• Adjunct treatment in Crohn’s disorders harming the rectum and distal colon.

By delivering mesalazine locally to the inflamed mucosa, Mesacol 1gm Suppository helps to minimize inflammation, manage symptoms like diarrhea, rectal bleeding, and abdominal pain, and better mucosal healing.

How Does Mesacol 1gm Suppository Work?

Mesalazine, the active pharmaceutical ingredient in Mesalazine Suppository 1gm, is basically an anti-inflammatory agent that acts locally within our colon. It blocks the creation of inflammatory mediators like leukotrienes and prostaglandins by inhibiting lipoxygenase and cyclooxygenase pathways. This mechanism minimizes inflammation and oxidative stress (OS) in the intestinal lining. Unlike traditional systemic corticosteroids available on the market, mesalazine targets the inflamed tissue selectively with minimal systemic absorption, which reduces the risk of undesirable side effects.

Benefits of Mesacol 1gm Suppository

• It offers a targeted anti-inflammatory effect directly at the site of inflammation.
• Minimize symptoms like pain, rectal bleeding, and diarrhea effectively.
• Helps to minimize and maintain remission in proctitis and ulcerative colitis.
• Reduce systemic side effects in comparison with oral therapies.
• Reliable medication and easy-to-use rectal administration.
• Supports better quality of life by managing flare-ups and boosting healing.

Side Effects of Mesacol 1gm Suppository

• Mild abdominal cramps
• Rectal irritation or discomfort
• Nausea
• Diarrhea
• Headache
• Rash or skin reactions
• Fever (rare)
• Allergic reactions (rare)
• Vomiting (rare)

If you experience undesirable side effects like swelling, difficulty breathing, or severe rash, call your doctor immediately and get medical attention fast.

Dosage

The standard Mesacol 1gm dosage for adults is one suppository inserted rectally once or twice daily, varying on the severity of the situation and the prescribing doctor’s suggestions. For maintenance treatment, the dosage may be decreased to once a day. It is crucial to follow the dose regimen prescribed by your healthcare expert and complete the entire course of treatment to get optimal results.

Remember, you should insert the medicine (suppository) after bowel movements and ideally at bedtime to make the most of contact time with the rectal mucosa. However, never use more than the suggested dose to avoid irritation.

Mesacol Tablet Strengths:

• Mesacol 500 mg
• Mesacol 800 mg
• Mesacol 1200 Mg
• Mesacol 2gm Granules

Drug Interactions

• Methotrexate
• Azathioprine
• Corticosteroids
• Sulfasalazine
• Other non-steroidal anti-inflammatory drugs (NSAIDs)
• Antacids containing aluminum or magnesium

You should always consult your physician about all supplements and medicines you are using to prevent potential drug interactions.

Warnings

• You should not use Mesacol Suppository for Proctitis if you have an allergic issue with mesalazine or any other component of the product.
• Consult your doctor if you have renal or liver issues before starting medication.
• Use with care if you have a history of severe allergies or blood disorders.
• Pregnant women and breastfeeding mothers should discuss with their healthcare expert before using the medicine.
• Avoid inserting the suppository if you feel severe obstruction or rectal bleeding.
• Store the medicine (suppositories) in a dry and cool area, away from direct heat and sunlight. Keep it at a safe distance from your children.